I never bought their marriage to begin with and honestly, I think it should be obvious to anyone who didn't have the "House/Cameron" bug like I do that it was contrived and stupid.
Let's start at the beginning. The beginning of Chase and Cameron's relationship: Cameron snags some methamphetamine from a homosexual party-boy who's dying of HIV and calls Chase over to essentially "live it up" and jump his bones. This is after what appears to be a several month long dry spell in which, for all intents and purposes, it seems as if Cameron hadn't touched a single human male. Big romance.
Then, they start to do it more with absolutely zero implied emotional context. Later on, it makes it look like Chase is more into her that she is into him, suggesting that perhaps at the beginning of their arrangement, Chase got more emotionally out of being physical with her than she did, but that's not even supported by ANYTHING we ever saw on screen. They were, essentially, pure **** buddies.
Later on, I don't even remember when, but they break it off because Chase seems to be getting too serious about it, and Cameron cuts it off.
Later, AS FAR AS ANYONE CAN TELL, Cameron gives him a second chance basically just to prove to House she's not still in love with him. Wow, what a foundation for a relationship. The only additional dimension that could have any remotely genuine emotional context to it at all is that we presume Cameron is still lonely because she doesn't appear to be seeing ANYONE else this entire time.
Enter Season 4 and 5 where we didn't see Cameron or Chase for like 5 episodes at a time because House fired Chase and Cameron quit. All the sudden they're moving in together and, through the magic of the "perfectly developing offscreen romance", they're doing stellar. No relationship foundation? Oh well.
So then, we have like, 1 or 2 episodes, that just pop up out of NOWHERE in which this completely manufactured angst is injected into the plot, like we're suddenly supposed to have our heartstrings tugged when Cameron and Chase have problems. Why? Since when are they even serious? Oh yeah, it happened off screen, which makes it real... right? Not really.
So then they are talking about getting married. What? GETTING
married?! Ok, we're tired of trying to follow this emotional vacuum of a relationship, so we just say "ok, whatever, get on with it."
In the end of Season 5, Cameron and Chase's wedding pretty much just serves the purpose of adding a nice little crescendo to the whole "everyone is happy except House" ambience whose little concertos include Cuddy with her baby, Foreman and Thirteen happy, and of course, the budding young romance between Chase and Cameron culminating in the ultimately symbolic abandonment of her feelings for House and thus moving on and thus House being alone.... their wedding.
So basically, when they start having these Dubala-related problems, we're supposed to just forget that the entire relationship has been contrived and illogical and hollow and senseless from the beginning and suddenly CARE how and why it ends. Unfortunately it leads to the departure of one of my favorite characters, even when she's totally clothed

But I think we lose what was, when she wasn't being morally infantile, probably THE ONLY interesting character on the show who could stand toe-to-toe with House without sounding like a whiney uptown cocky yuppy (Foreman), a bad actress (Thirteen), or morally empty jerkface (Chase).